Tocotrienol belongs to the Vitamin E family. It has various health benefits. Amongst them, it is considered as brain nutrition. They are found in very low levels in nature. While it is available in rice bran, barly etc., it is available relatively more in palm fruit. In case of deficiency, a natural supplement is the solution.
When we talk about ischemia, invariably we will think about cardio related aspects. However, there are many ischemic conditions. The damage to tissues of important organs in our body like the heart and brain are not only caused by a deficiency of oxygen, but also due to various other factors. In the case of brain, glutamate could be responsible.
Glutamate is the common neurotransmitter found in the brain. It is excitatory in nature. If this is released excessively, it becomes toxic and leads to the destruction of the tissues of the brain. This condition is known as brain ischemia. It is glutamate induced neurodegeneration. Unless checked, it will lead to even stroke.
How we can facilitate our system to support against degeneration? If we offer some nutrition to our system that can inspect and allow only allied and friendly inputs to the brain tissues and block enemy inputs, we have solved the problem.
Palm fruit has tocotrienol. This vitamin acts on key molecular checkpoints to protect against glutamate induced ischemia and protect the brain. Hence it is one of the good brain nutrition.
From the normal diet, getting adequate amount of this nutrition is impossible. One should be particular to get it from palm fruit and not from other natural sources. One cup of palm oil is required to get adequate amount of this vitamin. But that is impractical. The only alternative is to go in for tocotrienol supplement. Again one should be careful not to fall pray to synthetically produced supplement.
I know for sure a fantastic nutritional supplement produced out of exclusive hundred percent natural sources like herbs, sea salts etc. Also the facility is fully GMP compliant. The product offers complete nutrition in planned format including this vitamin extracted from palm fruit. You will not only get the benefit of this brain nutrition, but also nutrition for each and every organ of our body. You will be delighted when you get into my website to know more about nutrition, health and wellness and I am sure you will greatly benefit.
Michael Ryan is an expert on nutritional supplements and has over 30years experience in the health and wellness industry.Check out his web site at http://www.nutritionflash.com to find out which nutrition and vitamin supplements you must consider taking.
The vitamin E family comprised of eight chemically distinct compounds: 4 tocopherols and 4 tocotrienols (alpha, beta, gamma and delta). Tocotrienols differ from tocopherols by having an unsaturated side tail that results in significantly different biological activities.
ตอบลบHow does palm tocotrienol complex confer neuroprotection?
1) Tocotrienol has been reported to cross the blood-brain barrier. Alpha-tocotrienol was reported in the Journal of Biological Chemistry to be much more potent than the regular alpha-tocopherol in protecting the brain cells / neurons from glutamate-induced toxicity. For full protection, nanomolar level of tocotrienol was required whereas the regular tocopherol requires micromolar level – a 1000X more potent. Carotech’s research collaboration with the Ohio State University Medical Center on Tocomin® and potent neuro-protection has recently received a research grant in excess of USD 1 million from the United States’ National Institute of Health.
2) Palm tocotrienol complex is a much more potent antioxidant than tocopherol. It has been shown by published research paper that alpha-tocotrienol is 40 – 60 times more potent than alpha-tocopherol in the prevention of lipid peroxidation.
3) Tocotrienols, with their unsaturated side chain, allow them to pass through the membrane bi-layer (mainly made up of unsaturated fatty acid) in a more efficient manner and faster rate compared to the all saturated tocopherol.
To be continued
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ตอบลบContinued from below
ตอบลบIn summary, there are 2 main actions how palm tocotrienol complex confer neuroprotection:
a. through powerful antioxidant function as mentioned above
b. through mechanisms other than antioxidant function - Tocotrienol protects neuron death by other mechanism unrelated to its antioxidant activity. In a number of NIH-sponsored studies, Researchers at the Ohio State Medical Center showed that alpha-tocotrienol, but not alpha-tocopherol, prevented neuron’s death at extremely low concentration (nanomolar, 10-9) by regulating specific mediators of cell death (Sen CK et al., 2000). Tocotrienol-treated neurons maintained healthy growth and motility even in the presence of excess neurotoxic agent. The neuroprotective property seen at such low concentration of tocotrienol is independent of its antioxidant activity, as tocotrienols do not exhibit antioxidant properties at nanomolar concentrations. Tocotrienols only begins to show its antioxidant effects at micromolar concentrations (Khanna et al., 2006).
The same researchers went on to demonstrate that oral supplementation of tocotrienols (Tocomin®) reaches rats’ brain in concentration that protected against stroke. There is reduced volume of cerebral infarct in tocotrienol-supplemented rats compared with un-supplemented controls (Khanna S et al., 2005).
A further study showed that Tocomin®SupraBio™ supplementation in healthy women achieved plasma levels of tocotrienols 12 to 30 times more than the concentration of α-tocotrienol required to completely prevent stroke-related neurodegeneration (Khosla P et al., 2006).
With the above research, a clinical trial is now ongoing to study the neuroprotective effects of palm tocotrienol complex. This is the first study of its kind and the world’s largest clinical trial utilizing MRI brain to evaluate the efficacy of palm tocotrienol complex in neuroprotection and antiatherogenic function in human. The results of this clinical trial will shed more light on the benefits of palm tocotrienol complex (Tocomin®) in both acute neurological disorders (e.g. stroke) and chronic neurodegenerative disorders (e.g. Alzheimer’s disease; Parkinson’s disease).
For more information, please visit www.tocotrienol.org or follow latest research update on palm tocotrienol complex through http://www.facebook.com/CarotechInc